Supporting Data and White Papers
December 17, 2024
Antibiotic Release Kinetics from the Vetlen Pouch
Vetlen Pouch is designed for continuous, localized dosing of small, water-soluble therapeutics (<2 kDa) directly to surgical sites. Its rate-controlling membrane allows passive diffusion, maintaining high therapeutic concentrations in the target tissues. We've empirically tested permeability and solubility limits for a range of relevant veterinary therapeutics, providing a reliable dosing guide for your patient’s specific needs.
For best results, use the highest antibiotic dose within the daily maximum limit. This optimizes the diffusive antibiotic field around Vetlen Pouch. If the recommended dose exceeds the solubility or loading limits, dose to the lowest limit. For our equine patients, if the recommended dose is greater than the maximum volume of the pouch, dose to maximum volume of the pouch.
Caution is advised when selecting antibiotics. Some formulations that appear soluble in the vial may contain excipients that suspend insoluble compounds. These are unsuitable for the Vetlen Pouch, as insoluble compounds may precipitate, reducing the active antibiotic fraction and complicating dosing and device removal.
November 20, 2024
Plasma Concentrations of Amikacin - Vetlen Pouch vs. Systemic Administration
Summary of analysis completed by Mark Papich, DVM, MS, DACVCP, Professor of Clinical Pharmacology, North Carolina State University College of Veterinary Medicine. As shown in the figure with simulated plasma concentrations from multiple IV doses at 15 mg/kg, compared to the concentrations from Vetlen Pouch, the concentrations from Vetlen Pouch are significantly less. The peak concentration from IV administration was approximately 69 μg/mL, but the peak concentration from Vetlen Pouch was approximately 6 μg/mL over 7 doses. These concentrations are unlikely to produce any adverse effects in dogs.
October 24, 2024
Refillable Drug Delivery Device to Manage Infection Poster
Discover the Science Behind Vetlen's Pouch. Download Vetlen's 2024 ACVS Surgery Summit Poster shows why the pouch is a refillable drug delivery device that sustains local, high dose antibiotic therapy in an injury site.
June 18, 2024
What is Biofilm & Why Does it Matter?
Biofilms are complex communities of microorganisms that adhere to surfaces and are encased in a protective matrix, complicating surgical infection treatment and posing a significant challenge for veterinarians.