Supporting Data

March 17, 2025

In vivo efficacy of a refillable intrawound drug delivery device in a sheep model of biofilm-compromised open fracture-related infection

Purgo Scientific's seminal paper on the Purgo Pouch demonstrates the significant potential of sustained antibiotic release into local tissues through passive diffusion for managing biofilm-related infections. This foundational work paved the way for the introduction of the Vetlen Pouch in veterinary medicine. The paper was published in Biofilm, a leading peer-reviewed journal by Elsevier focused on biofilms and featured in a special issue of the Approaching Zero Initiative.

Read The Publication

December 17, 2024

Antibiotic Release Kinetics from the Vetlen Pouch

Vetlen Pouch is designed for continuous, localized dosing of small, water-soluble therapeutics (<2 kDa) directly to surgical sites. Its rate-controlling membrane allows passive diffusion, maintaining high therapeutic concentrations in the target tissues. We've empirically tested permeability and solubility limits for a range of relevant veterinary therapeutics, providing a reliable dosing guide for your patient’s specific needs.

For best results, use the highest antibiotic dose within the daily maximum limit. This optimizes the diffusive antibiotic field around Vetlen Pouch. If the recommended dose exceeds the solubility or loading limits, dose to the lowest limit. For our equine patients, if the recommended dose is greater than the maximum volume of the pouch, dose to maximum volume of the pouch.

Caution is advised when selecting antibiotics. Some formulations that appear soluble in the vial may contain excipients that suspend insoluble compounds. These are unsuitable for the Vetlen Pouch, as insoluble compounds may precipitate, reducing the active antibiotic fraction and complicating dosing and device removal.

Read The White Paper

November 20, 2024

Plasma Concentrations of Amikacin - Vetlen Pouch vs. Systemic Administration

Summary of analysis completed by Mark Papich, DVM, MS, DACVCP, Professor of Clinical Pharmacology, North Carolina State University College of Veterinary Medicine. As shown in the figure with simulated plasma concentrations from multiple IV doses at 15 mg/kg, compared to the concentrations from Vetlen Pouch, the concentrations from Vetlen Pouch are significantly less. The peak concentration from IV administration was approximately 69 μg/mL, but the peak concentration from Vetlen Pouch was approximately 6 μg/mL over 7 doses. These concentrations are unlikely to produce any adverse effects in dogs.

Read The Study

October 24, 2024

Refillable Drug Delivery Device to Manage Infection Poster

Discover the Science Behind Vetlen's Pouch. Download Vetlen's 2024 ACVS Surgery Summit Poster shows why the pouch is a refillable drug delivery device that sustains local, high dose antibiotic therapy in an injury site.

View The Poster

June 18, 2024

What is Biofilm & Why Does it Matter?

Biofilms are complex communities of microorganisms that adhere to surfaces and are encased in a protective matrix, complicating surgical infection treatment and posing a significant challenge for veterinarians.