Vetlen Scientific Research & Supporting Publications
University of Tennessee Review Highlights Local Antibiotic Delivery in Veterinary MedicineΒ
March 17, 2025
In vivo efficacy of a refillable intrawound drug delivery device in a sheep model of biofilm-compromised open fracture-related infection
Purgo Scientific's seminal paper on the Purgo Pouch demonstrates the significant potential of sustained antibiotic release into local tissues through passive diffusion for managing biofilm-related infections. This foundational work paved the way for the introduction of the Vetlen Pouch in veterinary medicine. The paper was published in Biofilm, a leading peer-reviewed journal by Elsevier focused on biofilms and featured in a special issue of the Approaching Zero Initiative.
November 20, 2024
Plasma Concentrations of Amikacin - Vetlen Pouch vs. Systemic Administration
Summary of analysis completed by Mark Papich, DVM, MS, DACVCP, Professor of Clinical Pharmacology, North Carolina State University College of Veterinary Medicine. As shown in the figure with simulated plasma concentrations from multiple IV doses at 15 mg/kg, compared to the concentrations from Vetlen Pouch, the concentrations from Vetlen Pouch are significantly less. The peak concentration from IV administration was approximately 69 ΞΌg/mL, but the peak concentration from Vetlen Pouch was approximately 6 ΞΌg/mL over 7 doses. These concentrations are unlikely to produce any adverse effects in dogs.Β
October 24, 2024
Refillable Drug Delivery Device to Manage Infection Poster
Discover the Science Behind Vetlen's Pouch. Download Vetlen's 2024 ACVS Surgery Summit Poster shows why the pouch is a refillable drug delivery device that sustains local, high dose antibiotic therapy in an injury site.
June 18, 2024
What is Biofilm & Why Does it Matter?
Biofilms are complex communities of microorganisms that adhere to surfaces and are encased in a protective matrix, complicating surgical infection treatment and posing a significant challenge for veterinarians.